Spellman PT, Sherlock G, Zhang MQ, Iyer VR, Anders K, Eisen MB, Brown PO, Botstein D, Futcher B. Perou CM, Sorlie T, Eisen MB, van de Rijn M, Jeffrey SS, Rees CA, Pollack JR, Ross DT, Johnsen H, Akslen LA, Fluge O, Pergamenschikov A, Williams C, Zhu SX, Lonning PE, Borresen-Dale AL, Brown PO, Botstein D. Perou CM, Jeffrey SS, van de Rijn M, Rees CA, Eisen MB, Ross DT, Pergamenschikov A, Williams CF, Zhu SX, Lee JC, Lashkari D, Shalon D, Brown PO, Botstein D. Moch H, Schraml P, Bubendorf L, Mirlacher M, Kononen J, Gasser T, Mihatsch MJ, Kallioniemi OP, Sauter G. Luo L, Salunga RC, Guo H, Bittner A, Joy KC, Galindo JE, Xiao H, Rogers KE, Wan JS, Jackson MR, Erlander MG. Iyer VR, Eisen MB, Ross DT, Schuler G, Moore T, Lee JCF, Trent JM, Staudt LM, Hudson Jr J, Boguski MS, Lashkari D, Shalon D, Botstein D, Brown PO. 303: 179–205Įisen MB, Spellman PT, Brown PO, Botstein D. 1998 Science 282: 699–705 Erratum published Science 282 1421ĭaly JM, Fry WA, Little AG, Winchester DP, McKee RF, Stewart AK, Fremgen AM. 162: 156–159Ĭhu S, DeRisi J, Eisen M, Mulholland J, Botstein D, Brown PO, Herskowitz I. 2000 Nature 403: 503–511īassett Jr DE, Eisen MB, Boguski MS. 18: 373–379Īlizadeh AA, Eisen MB, Davis RE, Ma C, Lossos IS, Rosenwald A, Boldrick JC, Sabet H, Tran T, Yu X, Powell JI, Yang L, Marti GE, Moore T, Hudson Jr J, Lu L, Lewis DB, Tibshirani R, Sherlock G, Chan WC, Greiner TC, Weisenburger DD, Armitage JO, Warnke R, Staudt LM, Levy R, Wilson W, Glever M, Byrd J, Botstein D, Brown PO. We conclude that cDNA microarrays and bioinformatics show promise in the classification of esophageal malignant and premalignant diseases, and that these methods can be applied to small biopsy samples.Īlizadeh A, Eisen M, Botstein D, Brown PO, Staudt LM. Thus, squamous cell carcinomas (SCCAs) constituted one group, adenocarcinomas (ADCAs) clustered separately, and one signet-ring carcinoma was in its own cluster, distinct from the ADCA cluster. The cancers also clustered according to histopathological subtype. After retrieving histologic reports for these tissues, we found that one main cluster contained all seven Barrett's samples, while the remaining principal cluster comprised the six esophageal cancers. The esophageal samples clustered naturally into two principal groups, each possessing unique global gene expression profiles. Hierarchical cluster analysis was performed on these results and displayed using a color-coded graphic representation (Treeview). We hybridized microarrays, each containing 8000 cDNA clones, to RNAs extracted from 13 esophageal surgical or endoscopic biopsy specimens (seven Barrett's metaplasias and six esophageal carcinomas). TreeView.addEventHandler(MouseEvent.In order to identify and contrast global gene expression profiles defining the premalignant syndrome, Barrett's esophagus, as well as frank esophageal cancer, we utilized cDNA microarray technology in conjunction with bioinformatics tools. StackPane.getChildren().setAll(treeView) This was actually a logic error in my program, however it does seem this is not desired behaviour and may point to an underlying issue. When setting the root of a TreeView, calling clear on it, populating it and then clearing it again, an IndexOutOfBoundsException is triggered.
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